Voici les horaires habituels des TGV sur leurs principales destinations.
| TRAJET | TRAINS PAR JOUR | PREMIER TRAIN | DERNIER TRAIN | DUREE MOYENNE | LE PLUS RAPIDE | CHANGEMENTS |
|---|---|---|---|---|---|---|
| Paris – Lyon | 33 | 05:50 | 20:59 | 1 h 57 | 1 h 52 | Direct |
| Lyon – Paris | 33 | 06:04 | 21:04 | 2 h 00 | 1 h 53 | Direct |
| Paris – Bordeaux | 21 | 06:09 | 20:57 | 2 h 11 | 2 h 04 | Direct |
| Bordeaux – Paris | 21 | 05:46 | 21:04 | 2 h 09 | 2 h 03 | Direct |
| Paris – Lille | 22 | 06:46 | 21:28 | 1 h 04 | 59 mn | Direct |
| Lille – Paris | 21 | 05:51 | 21:20 | 1 h 12 | 1 h 01 | Direct |
| Paris – Nantes | 18 | 06:23 | 21:48 | 2 h 06 | 1 h 56 | Direct |
| Nantes – Paris | 18 | 05:00 | 20:06 | 2 h 13 | 1 h 58 | Direct |
| Paris – Marseille | 16 | 06:07 | 20:19 | 3 h 29 | 3 h 11 | Direct |
| Marseille – Paris | 15 | 05:19 | 19:04 | 3 h 26 | 3 h 09 | Direct |
| Paris – Strasbourg | 15 | 06:40 | 20:25 | 1 h 51 | 1 h 45 | Direct |
| Strasbourg – Paris | 16 | 05:41 | 20:19 | 1 h 54 | 1 h46 | Direct |
| Paris – Rennes | 20 | 06:56 | 21:14 | 1 h 37 | 1 h 25 | Direct |
| Rennes – Paris | 19 | 05:36 | 21:35 | 1 h 43 | 1 h 26 | Direct |
| Paris – Aix-en-Provence | 19 | 07:37 | 20:57 | 5 h 14 | 4 h 32 | 1 |
| Aix-en-Provence – Paris | 22 | 05:49 | 17:48 | 4 h 43 | 4 h 27 | 1 |